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Il bioconjugation e radiosintesi di<sup> 89</sup> Anticorpi Zr-DFO-etichettati
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Chemistry
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JoVE Journal Chemistry
The Bioconjugation and Radiosynthesis of 89Zr-DFO-labeled Antibodies
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Il bioconjugation e radiosintesi di<sup> 89</sup> Anticorpi Zr-DFO-etichettati

italiano

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16,687 Views

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09:29 min

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February 12, 2015

DOI:

10.3791/52521-v

DOI:
10.3791/52521-v

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09:29 min
February 12, 2015

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19 Views
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1Department of Radiology,Memorial Sloan Kettering Cancer Center

Summary

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Due to its multi-day radioactive half-life and favorable decay properties, the positron-emitting radiometal 89Zr is extremely well-suited for use in antibody-based radiopharmaceuticals for PET imaging. In this protocol, the bioconjugation, radiosynthesis, and preclinical application of 89Zr-labeled antibodies will be described.

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Cite this Article

Zeglis, B. M., Lewis, J. S. The Bioconjugation and Radiosynthesis of 89Zr-DFO-labeled Antibodies. J. Vis. Exp. (96), e52521, doi:10.3791/52521 (2015).

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