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Amida de reacción para la Síntesis de ligandos basados ​​en bispiridina y su complejación a Platinum como dinucleares Agentes anticancerígenos
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JoVE Journal Chemistry
Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
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Amida de reacción para la Síntesis de ligandos basados ​​en bispiridina y su complejación a Platinum como dinucleares Agentes anticancerígenos

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13,800 Views

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07:20 min

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May 28, 2014

DOI:

10.3791/51740-v

DOI:
10.3791/51740-v

•

07:20 min
May 28, 2014

•

1 Views
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1Faculty of Pharmacy,The University of Sydney, 2School of Science and Health,University of Western Sydney, 3Division of Chemistry and Environmental Science, School of Science and the Environment,Manchester Metropolitan University, 4Nature Publishing Group

Summary

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Este protocolo describe el uso de reacciones de acoplamiento de amida del ácido isonicotínico y diaminoalcanos para formar ligandos puente adecuados para su uso en la síntesis de complejos de platino multinucleares, que combinan aspectos de los medicamentos contra el cáncer BBR3464 y picoplatin.

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Cite this Article

Apps, M. G., Johnson, B. W., Sutcliffe, O. B., Brown, S. D., Wheate, N. J. Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents. J. Vis. Exp. (87), e51740, doi:10.3791/51740 (2014).

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