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Amide Réaction de couplage pour la synthèse de ligands à base de bispyridine et leur complexation Platinum comme dinucléaires agents anticancéreux
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Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
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Amide Réaction de couplage pour la synthèse de ligands à base de bispyridine et leur complexation Platinum comme dinucléaires agents anticancéreux

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13,800 Views

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07:20 min

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May 28, 2014

DOI:

10.3791/51740-v

DOI:
10.3791/51740-v

•

07:20 min
May 28, 2014

•

1 Views
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1Faculty of Pharmacy,The University of Sydney, 2School of Science and Health,University of Western Sydney, 3Division of Chemistry and Environmental Science, School of Science and the Environment,Manchester Metropolitan University, 4Nature Publishing Group

Summary

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Ce protocole décrit l'utilisation de réactions de couplage de l'amide d'acide isonicotinique et diaminoalcanes pour former ligands pontants appropriés pour une utilisation dans la synthèse de complexes de platine polynucléaires, qui combinent les aspects des médicaments anticancéreux et BBR3464 picoplatin.

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Cite this Article

Apps, M. G., Johnson, B. W., Sutcliffe, O. B., Brown, S. D., Wheate, N. J. Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents. J. Vis. Exp. (87), e51740, doi:10.3791/51740 (2014).

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