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Amidekoppeling reactie voor de synthese van Bispyridine-gebaseerde liganden en hun Complexatie naar Platinum als dinucleair antikankermiddelen
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JoVE Journal Chemistry
Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
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Amidekoppeling reactie voor de synthese van Bispyridine-gebaseerde liganden en hun Complexatie naar Platinum als dinucleair antikankermiddelen

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13,800 Views

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07:20 min

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May 28, 2014

DOI:

10.3791/51740-v

DOI:
10.3791/51740-v

•

07:20 min
May 28, 2014

•

1 Views
, , , ,
1Faculty of Pharmacy,The University of Sydney, 2School of Science and Health,University of Western Sydney, 3Division of Chemistry and Environmental Science, School of Science and the Environment,Manchester Metropolitan University, 4Nature Publishing Group

Summary

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Dit protocol beschrijft het gebruik van amide koppelingsreacties van isonicotinezuur en diaminoalkanes te overbruggen liganden geschikt voor gebruik in de synthese van meerkernige platina complexen, die aspecten van de antikankergeneesmiddelen BBR3464 en picoplatin combineren vormen.

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Cite this Article

Apps, M. G., Johnson, B. W., Sutcliffe, O. B., Brown, S. D., Wheate, N. J. Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents. J. Vis. Exp. (87), e51740, doi:10.3791/51740 (2014).

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