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Functional Interrogation of Adult Hypothalamic Neurogenesis with Focal Radiological Inhibition
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11:45 min
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November 14, 2013
DOI:
1Division of Biology,California Institute of Technology, 2Solomon H. Snyder Department of Neuroscience, Neurology, and Ophthalamology,Johns Hopkins University School of Medicine, 3Department of Radiation Oncology & Molecular Radiation Sciences,Johns Hopkins University School of Medicine, 4Department of Radiation Oncology,University Of Washington Medical Center, 5Institute for Cell Engineering and High-Throughput Biology Center,Johns Hopkins University School of Medicine
Summary
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The function of adult-born mammalian neurons remains an active area of investigation. Ionizing radiation inhibits the birth of new neurons. Using computer tomography-guided focal irradiation (CFIR), three-dimensional anatomical targeting of specific neural progenitor populations can now be used to assess the functional role of adult neurogenesis.
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Lee, D. A., Salvatierra, J., Velarde, E., Wong, J., Ford, E. C., Blackshaw, S. Functional Interrogation of Adult Hypothalamic Neurogenesis with Focal Radiological Inhibition. J. Vis. Exp. (81), e50716, doi:10.3791/50716 (2013).
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