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の臨床応用<em>眠れる森の美女</em遺伝的に末梢及び臍帯血由来のT細胞を変更する>と人工抗原提示細胞
JoVE Journal
Immunology and Infection
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JoVE Journal Immunology and Infection
Clinical Application of Sleeping Beauty and Artificial Antigen Presenting Cells to Genetically Modify T Cells from Peripheral and Umbilical Cord Blood
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の臨床応用<em>眠れる森の美女</em遺伝的に末梢及び臍帯血由来のT細胞を変更する>と人工抗原提示細胞

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18,083 Views

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09:29 min

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February 01, 2013

DOI:

10.3791/50070-v

DOI:
10.3791/50070-v

•

09:29 min
February 01, 2013

•

3 Views
, , , , , , , ,
1Division of Pediatrics,U.T. MD Anderson Cancer Center, 2Department of Stem Cell Transplantation and Cellular Therapy,U.T. MD Anderson Cancer Center

Summary

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CD19特異的キメラ抗原受容体（CAR）を発現するT細胞は、私たちのファースト·イン·ヒトの遺伝子治療の臨床試験におけるB細胞悪性腫瘍の治験治療として注入される。我々は、使用して、T細胞の遺伝子改変を記述<em>眠れる森の美女</em>（SB）のデザイナー、CD19 +人工抗原提示細胞上のCD19特異的CARと選択的伝播を紹介するシステム。

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Sleeping BeautyArtificial Antigen Presenting CellsGenetic ModificationT CellsPeripheral BloodUmbilical Cord BloodCAR T CellsCD19Gene TherapyImmunotherapyTumor-associated AntigensClinical Application

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Cite this Article

Huls, M. H., Figliola, M. J., Dawson, M. J., Olivares, S., Kebriaei, P., Shpall, E. J., Champlin, R. E., Singh, H., Cooper, L. J. Clinical Application of Sleeping Beauty and Artificial Antigen Presenting Cells to Genetically Modify T Cells from Peripheral and Umbilical Cord Blood. J. Vis. Exp. (72), e50070, doi:10.3791/50070 (2013).

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