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A Molecular Readout of Long-term Olfactory Adaptation in C. elegans
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Neuroscience
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JoVE Journal Neuroscience
A Molecular Readout of Long-term Olfactory Adaptation in C. elegans

A Molecular Readout of Long-term Olfactory Adaptation in C. elegans

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10,627 Views

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11:30 min

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December 22, 2012

DOI:

10.3791/4443-v

DOI:
10.3791/4443-v

•

11:30 min
December 22, 2012

•

4 Views
, , ,
1Department of Biological Sciences and Institute for Neuroscience,George Washington University, 2Fred Hutchinson Cancer Research Center, 3Department of Cell and Tissue Biology,University of California San Francisco

Summary

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Here we describe a molecular readout of long-term olfactory adaptation in Caenorhabditis elegans. The Protein Kinase G, EGL-4, is necessary for stable adaptation responses in the primary sensory neuron pair called AWC. During prolonged odor exposure EGL-4 translocates from the cytosol to nucleus of the AWC.

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He, C., Lee, J. I., L'Etoile, N., O'Halloran, D. A Molecular Readout of Long-term Olfactory Adaptation in C. elegans. J. Vis. Exp. (70), e4443, doi:10.3791/4443 (2012).

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