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A Molecular Readout of Long-term Olfactory Adaptation in C. elegans
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December 22, 2012
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Here we describe a molecular readout of long-term olfactory adaptation in Caenorhabditis elegans. The Protein Kinase G, EGL-4, is necessary for stable adaptation responses in the primary sensory neuron pair called AWC. During prolonged odor exposure EGL-4 translocates from the cytosol to nucleus of the AWC.
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Molecular ReadoutLong-term Olfactory AdaptationC. ElegansSensory NeuronsAdaptation ResponseOlfactory CircuitGenetic ScreenMutantsVolatile OdorsAmphid Wing Cells Type C (AWC) Sensory NeuronsChemotaxis Behavioral AssayShort-term Olfactory AdaptationLong-term Olfactory AdaptationProtein Kinase G (PKG)EGL-4 Protein
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He, C., Lee, J. I., L'Etoile, N., O'Halloran, D. A Molecular Readout of Long-term Olfactory Adaptation in C. elegans. J. Vis. Exp. (70), e4443, doi:10.3791/4443 (2012).
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