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El uso de la fMRI farmacológico-reto en la investigación preclínica: la aplicación al sistema de 5-HT
JoVE Journal
Medicine
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JoVE Journal Medicine
The Use of Pharmacological-challenge fMRI in Pre-clinical Research: Application to the 5-HT System
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El uso de la fMRI farmacológico-reto en la investigación preclínica: la aplicación al sistema de 5-HT

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15,143 Views

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11:27 min

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April 25, 2012

DOI:

10.3791/3956-v

DOI:
10.3791/3956-v

•

11:27 min
April 25, 2012

•

1 Views
, , , ,
1Department of Radiology, Brain Imaging Center,Academic Medical Center Amsterdam, 2Biological Imaging Centre, MRC Clinical Sciences Centre,Imperial College London

Summary

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El objetivo de esta técnica consiste en evaluar la serotonina (5-HT) la función de neurotransmisor en el animal vivo y sin respiración, con imágenes de resonancia magnética farmacológica (phMRI) y un desafío por vía intravenosa con un inhibidor selectivo de la recaptación de serotonina (ISRS), fluoxetina.

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Klomp, A., Tremoleda, J. L., Schrantee, A., Gsell, W., Reneman, L. The Use of Pharmacological-challenge fMRI in Pre-clinical Research: Application to the 5-HT System. J. Vis. Exp. (62), e3956, doi:10.3791/3956 (2012).

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