Journal
/
Medicina
/
The Use of Pharmacological-challenge fMRI in Pre-clinical Research: Application to the 5-HT System
JoVE Revista
Medicina
This content is Free Access.
JoVE Revista Medicina
The Use of Pharmacological-challenge fMRI in Pre-clinical Research: Application to the 5-HT System

The Use of Pharmacological-challenge fMRI in Pre-clinical Research: Application to the 5-HT System

15,143 Views

•

11:27 min

•

April 25, 2012

DOI:

10.3791/3956-v

DOI:
10.3791/3956-v

•

11:27 min
April 25, 2012

•

1 Views
, , , ,
1Department of Radiology, Brain Imaging Center,Academic Medical Center Amsterdam, 2Biological Imaging Centre, MRC Clinical Sciences Centre,Imperial College London

Summary

Automatically generated

The goal of this technique is to assess serotonin (5-HT) neurotransmitter function in the live and free-breathing animal with pharmacological magnetic resonance imaging (phMRI) and an intravenous challenge with a selective serotonin reuptake inhibitor (SSRI), fluoxetine.

Explore More Videos

Pharmacological-challenge FMRIPre-clinical Research5-HT SystemNeurobiological MechanismsDrug ActionNeurotransmitter-related DisordersDepressionADHDImaging MethodsPETSPECTCTBrain DisordersNeuronal ConnectivityClinical InvestigationsMolecular Imaging StrategiesSpatial ResolutionContrast-agentRadio-labeled MoleculesIonizing RadiationsFunctional MRIPsycho-motor TaskAdaptation Of FMRISpecific Neurotransmitter SystemSerotonin (5-HT)Physiological ConditionsPathological Conditions

Read Article

Cite this Article

Klomp, A., Tremoleda, J. L., Schrantee, A., Gsell, W., Reneman, L. The Use of Pharmacological-challenge fMRI in Pre-clinical Research: Application to the 5-HT System. J. Vis. Exp. (62), e3956, doi:10.3791/3956 (2012).

Download .ris file

Copy

Share Video

.

Copy