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The Use of Pharmacological-challenge fMRI in Pre-clinical Research: Application to the 5-HT System
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April 25, 2012
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The goal of this technique is to assess serotonin (5-HT) neurotransmitter function in the live and free-breathing animal with pharmacological magnetic resonance imaging (phMRI) and an intravenous challenge with a selective serotonin reuptake inhibitor (SSRI), fluoxetine.
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Pharmacological-challenge FMRIPre-clinical Research5-HT SystemNeurobiological MechanismsDrug ActionNeurotransmitter-related DisordersDepressionADHDImaging MethodsPETSPECTCTBrain DisordersNeuronal ConnectivityClinical InvestigationsMolecular Imaging StrategiesSpatial ResolutionContrast-agentRadio-labeled MoleculesIonizing RadiationsFunctional MRIPsycho-motor TaskAdaptation Of FMRISpecific Neurotransmitter SystemSerotonin (5-HT)Physiological ConditionsPathological Conditions
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Klomp, A., Tremoleda, J. L., Schrantee, A., Gsell, W., Reneman, L. The Use of Pharmacological-challenge fMRI in Pre-clinical Research: Application to the 5-HT System. J. Vis. Exp. (62), e3956, doi:10.3791/3956 (2012).
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