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April 25, 2012
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这项技术的目的是评估5 - 羟色胺（5-HT）神经递质的功能，在生活和自由呼吸的动物药理磁共振成像（phMRI）和静脉注射一种选择性血清素再摄取抑制剂（SSRI），氟西汀挑战。
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Pharmacological-challenge FMRIPre-clinical Research5-HT SystemNeurobiological MechanismsDrug ActionNeurotransmitter-related DisordersDepressionADHDImaging MethodsPETSPECTCTBrain DisordersNeuronal ConnectivityClinical InvestigationsMolecular Imaging StrategiesSpatial ResolutionContrast-agentRadio-labeled MoleculesIonizing RadiationsFunctional MRIPsycho-motor TaskAdaptation Of FMRISpecific Neurotransmitter SystemSerotonin (5-HT)Physiological ConditionsPathological Conditions
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Klomp, A., Tremoleda, J. L., Schrantee, A., Gsell, W., Reneman, L. The Use of Pharmacological-challenge fMRI in Pre-clinical Research: Application to the 5-HT System. J. Vis. Exp. (62), e3956, doi:10.3791/3956 (2012).
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