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April 24, 2012
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Silk films are a novel class of biomaterials readily customizable for an array of biomedical applications. The presented silk film culture system is highly adaptable to a variety of in vitro analyses. This system represents a biomaterial design platform offering in vitro optimization before direct translation to in vivo models.
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Silk Film Culture SystemIn Vitro AnalysisBiomaterial DesignProtein-based BiomaterialsHigh Fidelity FabricationResearch Laboratory EnvironmentControllable Dimensional And Material CharacteristicsBiocompatibleCell AdhesionTopographic PatterningSurface ModificationDepot For Biologically Active MoleculesDrug Delivery ApplicationsCustom DesignDissolution And Degradation PropertiesTransparency For Imaging ApplicationsCell-silk Film Surface InteractionsCell ProliferationAlignmentTime-lapse Phase-contrast ImagingScanning Electron MicroscopyMetabolic ActivityNucleic Acid Content
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Lawrence, B. D., Pan, Z., Weber, M. D., Kaplan, D. L., Rosenblatt, M. I. Silk Film Culture System for in vitro Analysis and Biomaterial Design. J. Vis. Exp. (62), e3646, doi:10.3791/3646 (2012).
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