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Detectie van neuritische plaques in de ziekte van Alzheimer Mouse Model
JoVE Journal
Neuroscience
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JoVE Journal Neuroscience
Detection of Neuritic Plaques in Alzheimer’s Disease Mouse Model
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Detectie van neuritische plaques in de ziekte van Alzheimer Mouse Model

Nederlands

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36,170 Views

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06:02 min

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July 26, 2011

DOI:

10.3791/2831-v

DOI:
10.3791/2831-v

•

06:02 min
July 26, 2011

•

4 Views
, ,
1Department of Neuroscience,The University of British Columbia

Summary

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Een van de pathologische kenmerken van AD is de vorming van amyloïde eiwit β positief neuritische plaques. In dit protocol beschrijven we twee methoden om seniele plaques op te sporen in transgene muizen die model AD: immunohistochemische detectie met behulp van de ABC-en DAB-methode en fluorescerende detectie met behulp van thioflavin S kleuringsmethode.

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Cite this Article

Ly, P. T., Cai, F., Song, W. Detection of Neuritic Plaques in Alzheimer's Disease Mouse Model. J. Vis. Exp. (53), e2831, doi:10.3791/2831 (2011).

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