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Journal / Neuroscience / Detection of Neuritic Plaques in Alzheimer's…
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Neuroscience

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JoVE Journal Neuroscience
Detection of Neuritic Plaques in Alzheimer's Disease Mouse Model
 

Detection of Neuritic Plaques in Alzheimer's Disease Mouse Model

Article DOI: 10.3791/2831-v • 06:02 min • July 26th, 2011
July 26th, 2011 •
*1, *1, 1
1Department of Neuroscience, The University of British Columbia
* These authors contributed equally

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Automatic Translation

One of the pathological characteristics of AD is the formation of Amyloid β protein positive neuritic plaques. In this protocol we describe two methods to detect neuritic plaques in transgenic AD model mice: immunohistochemical detection using the ABC and DAB method and fluorescent detection using thioflavin S staining method.

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Neuritic Plaques Alzheimer's Disease Mouse Model Detection Amyloid Beta Protein APP Processing Pathway Immunohistochemical Method ABC Method DAB Method
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