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July 13, 2011
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Numerous recent studies have identified mutations in synaptic proteins associated with brain pathologies. Primary cultured cortical neurons offer great flexibility in examining the effects of these disease-associated proteins on dendritic spine morphology and motility.
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Dendritic SpinesMorphologyCultured NeuronsExcitatory ConnectionsSynapsesActinHebbian PlasticityNeuromodulatory SignalsNeural CircuitsInformation ProcessingSynaptic ProteinsDisease StatesSchizophreniaAutism Spectrum DisordersAberrant Spine PlasticityPathophysiologyCultured Cortical NeuronsHigh-resolution ImagingFixed CellsTime-lapse Imaging
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Srivastava, D. P., Woolfrey, K. M., Penzes, P. Analysis of Dendritic Spine Morphology in Cultured CNS Neurons. J. Vis. Exp. (53), e2794, doi:10.3791/2794 (2011).
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