È necessario avere un abbonamento a JoVE per visualizzare questo. Accedi o inizia la tua prova gratuita.
Analysis of Dendritic Spine Morphology in Cultured CNS Neurons
34,577 Views
•
11:48 min
•
July 13, 2011
DOI:
Summary
Automatically generated
Numerous recent studies have identified mutations in synaptic proteins associated with brain pathologies. Primary cultured cortical neurons offer great flexibility in examining the effects of these disease-associated proteins on dendritic spine morphology and motility.
Explore More Videos
Dendritic SpinesMorphologyCultured NeuronsExcitatory ConnectionsSynapsesActinHebbian PlasticityNeuromodulatory SignalsNeural CircuitsInformation ProcessingSynaptic ProteinsDisease StatesSchizophreniaAutism Spectrum DisordersAberrant Spine PlasticityPathophysiologyCultured Cortical NeuronsHigh-resolution ImagingFixed CellsTime-lapse Imaging
Read Article
Cite this Article
Srivastava, D. P., Woolfrey, K. M., Penzes, P. Analysis of Dendritic Spine Morphology in Cultured CNS Neurons. J. Vis. Exp. (53), e2794, doi:10.3791/2794 (2011).
Copy