Journal
/
Biochemie
/
Characterization of Ternary Complex Formation in PROTACs Using Biophysical Assays
/
Isothermal Titration Calorimetry for Evaluating PROTACS-Induced Ternary Complex Formation
JoVE Journal
Biochemie
Zum Anzeigen dieser Inhalte ist ein JoVE-Abonnement erforderlich.  Melden Sie sich an oder starten Sie Ihre kostenlose Testversion.
JoVE Journal Biochemie
Isothermal Titration Calorimetry for Evaluating PROTACS-Induced Ternary Complex Formation

Isothermal Titration Calorimetry for Evaluating PROTACS-Induced Ternary Complex Formation

Characterization of Ternary Complex Formation in PROTACs Using Biophysical Assays

DOI:
10.3791/200654-v

•

01:16 min

•

January 12, 2024

•

,
1Center for the Development of Therapeutics,The Broad Institute of MIT and Harvard

Tags

Isothermal Titration CalorimetryPROTACSTernary Complex FormationProteinDMSOMicro CalorimeterTitrationBinary ComplexVHL MZ1Brd4Positive Cooperativity

Embed

ZUR WIEDERGABELISTE HINZUFÜGEN

Usage Statistics

Verwandte Videos

Author Spotlight: Evaluating Biophysical Assays for Characterizing PROTACS Ternary Complexes

Isothermal Titration Calorimetry for Evaluating PROTACS-Induced Ternary Complex Formation

Biolayer Interferometry (BLI) for Evaluating PROTACS-Induced Ternary Complex Formation

Surface Plasmon Resonance (SPR) for Evaluating PROTACS-Induced Ternary Complex Formation

Read Article