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Characterization of Ternary Complex Formation in PROTACs Using Biophysical Assays
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Isothermal Titration Calorimetry for Evaluating PROTACS-Induced Ternary Complex Formation
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JoVE Revista Bioquímica
Isothermal Titration Calorimetry for Evaluating PROTACS-Induced Ternary Complex Formation

Isothermal Titration Calorimetry for Evaluating PROTACS-Induced Ternary Complex Formation

Characterization of Ternary Complex Formation in PROTACs Using Biophysical Assays

DOI:
10.3791/200654-v

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01:16 min

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January 12, 2024

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1Center for the Development of Therapeutics,The Broad Institute of MIT and Harvard

Tags

Isothermal Titration CalorimetryPROTACSTernary Complex FormationProteinDMSOMicro CalorimeterTitrationBinary ComplexVHL MZ1Brd4Positive Cooperativity

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