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Selection of Aptamers for Amyloid β-Protein, the Causative Agent of Alzheimer's Disease
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Neuroscience
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JoVE Journal Neuroscience
Selection of Aptamers for Amyloid β-Protein, the Causative Agent of Alzheimer's Disease

Selection of Aptamers for Amyloid β-Protein, the Causative Agent of Alzheimer's Disease

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19,194 Views

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15:23 min

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May 13, 2010

DOI:

10.3791/1955-v

DOI:
10.3791/1955-v

•

15:23 min
May 13, 2010

•

11 Views
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1Department of Neurology,David Geffen School of Medicine, 2Molecular Biology Institute,University of California, Los Angeles, 3Brain Research Institute,University of California, Los Angeles

Summary

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Aptamers are short ribo-/deoxyribo-oligonucleotides selected by in-vitro evolution methods based on affinity for a specific target. Aptamers are molecular recognition tools with versatile therapeutic, diagnostic, and research applications. We demonstrate methods for selection of aptamers for amyloid β-protein, the causative agent of Alzheimer's disease.

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AptamersAmyloid β-proteinAlzheimer’s DiseaseNeurodegenerative DisorderPresymptomatic DiagnosisEarly DiagnosisEffective TherapiesAβ AssembliesSynaptic DysfunctionNeuron LossAD EtiologyAD PathogenesisMolecular Recognition ToolsAntibodiesAptamers AdvantagesSELEX (systematic Evolution Of Ligands By Exponential Enrichment)

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Cite this Article

Rahimi, F., Bitan, G. Selection of Aptamers for Amyloid β-Protein, the Causative Agent of Alzheimer's Disease. J. Vis. Exp. (39), e1955, doi:10.3791/1955 (2010).

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