Selection of Aptamers for Amyloid &beta;-Protein, the Causative Agent of Alzheimer&#39;s Disease

Farid Rahimi; Gal Bitan

doi:10.3791/1955

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神経科学

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Selection of Aptamers for Amyloid β-Protein, the Causative Agent of Alzheimer's Disease

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神経科学

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JoVE Journal 神経科学

Selection of Aptamers for Amyloid β-Protein, the Causative Agent of Alzheimer's Disease

19,194 Views

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15:23 min

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May 13, 2010

DOI:

10.3791/1955-v

DOI:

10.3791/1955-v

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15:23 min

May 13, 2010

•

11 Views

Farid Rahimi¹, Gal Bitan^1,2,3

¹Department of Neurology,David Geffen School of Medicine, ²Molecular Biology Institute,University of California, Los Angeles, ³Brain Research Institute,University of California, Los Angeles

概要

Aptamers are short ribo-/deoxyribo-oligonucleotides selected by in-vitro evolution methods based on affinity for a specific target. Aptamers are molecular recognition tools with versatile therapeutic, diagnostic, and research applications. We demonstrate methods for selection of aptamers for amyloid β-protein, the causative agent of Alzheimer's disease.

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Selection of Aptamers for Amyloid β-Protein, the Causative Agent of Alzheimer's Disease

概要

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