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Selection of Aptamers for Amyloid β-Protein, the Causative Agent of Alzheimer's Disease
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Selection of Aptamers for Amyloid β-Protein, the Causative Agent of Alzheimer's Disease
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May 13, 2010
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Aptamers are short ribo-/deoxyribo-oligonucleotides selected by in-vitro evolution methods based on affinity for a specific target. Aptamers are molecular recognition tools with versatile therapeutic, diagnostic, and research applications. We demonstrate methods for selection of aptamers for amyloid β-protein, the causative agent of Alzheimer's disease.
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AptamersAmyloid β-proteinAlzheimer’s DiseaseNeurodegenerative DisorderPresymptomatic DiagnosisEarly DiagnosisEffective TherapiesAβ AssembliesSynaptic DysfunctionNeuron LossAD EtiologyAD PathogenesisMolecular Recognition ToolsAntibodiesAptamers AdvantagesSELEX (systematic Evolution Of Ligands By Exponential Enrichment)
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Rahimi, F., Bitan, G. Selection of Aptamers for Amyloid β-Protein, the Causative Agent of Alzheimer's Disease. J. Vis. Exp. (39), e1955, doi:10.3791/1955 (2010).
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