Bu içeriği görüntülemek için JoVE aboneliği gereklidir. Oturum açın veya ücretsiz deneme sürümünü başlatın.
A Rat Model of EcoHIV Brain Infection
Bölümler
- 00:04Introduction
- 00:39293FT Cell Virus Packaging
- 02:56EcoHIV-EGFP Virus Stereotaxic Surgery
- 04:44Brain Section Visualization
- 06:37Results: Representative Neurocognitive and Morphological Effects of EcoHIV Injection into the Rat Brain
- 07:51Conclusion
Here, we present a protocol to establish a new rat model of active HIV infection using chimeric HIV (EcoHIV), which is critical for enhancing our understanding of HIV-1 viral reservoirs in the brain and offering a system to study HIV-associated neurocognitive disorders and associated comorbidities (i.e., drug abuse).
