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A Rat Model of EcoHIV Brain Infection
 

A Rat Model of EcoHIV Brain Infection

Article DOI: 10.3791/62137-v 08:48 min January 21st, 2021
January 21st, 2021

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résumé

Here, we present a protocol to establish a new rat model of active HIV infection using chimeric HIV (EcoHIV), which is critical for enhancing our understanding of HIV-1 viral reservoirs in the brain and offering a system to study HIV-associated neurocognitive disorders and associated comorbidities (i.e., drug abuse).

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Keywords: Rat Model EcoHIV Brain Infection HIV Neurocognitive Disorders 293 T-cells Transfection Chimeric EcoHIV Lenti-X Concentrator P24 ELISA Stereotaxic Apparatus Brain Injection
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