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纤维蛋白富集和 tPA 敏感的光血栓形成卒中模型
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A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model
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纤维蛋白富集和 tPA 敏感的光血栓形成卒中模型

2,290 Views

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09:42 min

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June 04, 2021

DOI:

10.3791/61740-v

DOI:
10.3791/61740-v

•

09:42 min
June 04, 2021

•

8 Views
, ,
1Department of Anesthesiology, Taipei Veterans General Hospital,National Yang-Ming University School of Medicine, 2Department of Neuroscience, Center for Brain Immunology and Glia (BIG),University of Virginia School of Medicine

Özet

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传统的光血栓中风 （PTS） 模型主要诱导对组织纤溶酶原激活剂 （tPA） 溶解治疗具有高耐药性的致密血小板聚集体。本文通过共注射凝血酶和光敏染料进行光活化，引入了改良的小鼠PTS模型。凝血酶增强的 PTS 模型产生混合血小板：纤维蛋白凝块，并且对 tPA 溶栓高度敏感。

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Kuo, Y., Sun, Y., Kuan, C. A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model. J. Vis. Exp. (172), e61740, doi:10.3791/61740 (2021).

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