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Recording and Modulation of Epileptiform Activity in Rodent Brain Slices Coupled to Microelectrode Arrays
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Recording and Modulation of Epileptiform Activity in Rodent Brain Slices Coupled to Microelectrode Arrays

Recording and Modulation of Epileptiform Activity in Rodent Brain Slices Coupled to Microelectrode Arrays

14,182 Views

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10:24 min

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May 15, 2018

DOI:

10.3791/57548-v

DOI:
10.3791/57548-v

•

10:24 min
May 15, 2018

•

21 Views
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1Department of Neuroscience and Brain Technologies,Istituto Italiano di Tecnologia, 2Rehab Technologies,Istituto Italiano di Tecnologia

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We illustrate how to perform recording and electrical modulation of 4-aminopyridine-induced epileptiform activity in rodent brain slices using microelectrode arrays. A custom recording chamber maintains tissue viability throughout prolonged experimental sessions. Live electrode mapping and selection of stimulating pairs are performed by a custom graphical user interface.

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Panuccio, G., Colombi, I., Chiappalone, M. Recording and Modulation of Epileptiform Activity in Rodent Brain Slices Coupled to Microelectrode Arrays. J. Vis. Exp. (135), e57548, doi:10.3791/57548 (2018).

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