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An In Vitro Caseum Binding Assay that Predicts Drug Penetration in Tuberculosis Lesions
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An In Vitro Caseum Binding Assay that Predicts Drug Penetration in Tuberculosis Lesions
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May 08, 2017
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Here we describe a rapid equilibrium dialysis (RED) method to measure drug binding to caseum from pulmonary tuberculosis lesions and cavities. The protocol is also used with a foamy macrophage-derived matrix that is an effective surrogate to caseum.
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Sarathy, J. P., Liang, H. H., Weiner, D., Gonzales, J., Via, L. E., Dartois, V. An In Vitro Caseum Binding Assay that Predicts Drug Penetration in Tuberculosis Lesions. J. Vis. Exp. (123), e55559, doi:10.3791/55559 (2017).
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