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在转基因小鼠神经炎症的生物发光成像的α-共核蛋白纤丝的外围接种后
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Bioluminescence Imaging of Neuroinflammation in Transgenic Mice After Peripheral Inoculation of Alpha-Synuclein Fibrils
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在转基因小鼠神经炎症的生物发光成像的α-共核蛋白纤丝的外围接种后

8,386 Views

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09:32 min

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April 13, 2017

DOI:

10.3791/55503-v

DOI:
10.3791/55503-v

•

09:32 min
April 13, 2017

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7 Views
, , , , ,
1German Center for Neurodegenerative Diseases (DZNE), 2Centre for Prions and Protein Folding Diseases & Department of Biochemistry,Alberta Üniversitesi

Özet

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外周注射的α-突触核蛋白原纤维进入的Tg的腹膜或舌的（M83 +/-：GFAP -luc +/-）小鼠，表达人α-突触核蛋白与家族性A53T突变和萤火虫萤光素酶，可诱发神经病理学，包括神经炎症在他们的中枢神经系统。

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Breid, S., Bernis, M. E., Tachu, J. B., Garza, M. C., Wille, H., Tamgüney, G. Bioluminescence Imaging of Neuroinflammation in Transgenic Mice After Peripheral Inoculation of Alpha-Synuclein Fibrils. J. Vis. Exp. (122), e55503, doi:10.3791/55503 (2017).

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