ジャーナル
/
神経科学
/
Bioluminescence Imaging of Neuroinflammation in Transgenic Mice After Peripheral Inoculation of Alpha-Synuclein Fibrils
JoVE Journal
神経科学
このコンテンツを視聴するには、JoVE 購読が必要です。  サインイン又は無料トライアルを申し込む。
JoVE Journal 神経科学
Bioluminescence Imaging of Neuroinflammation in Transgenic Mice After Peripheral Inoculation of Alpha-Synuclein Fibrils

Bioluminescence Imaging of Neuroinflammation in Transgenic Mice After Peripheral Inoculation of Alpha-Synuclein Fibrils

8,386 Views

•

09:32 min

•

April 13, 2017

DOI:

10.3791/55503-v

DOI:
10.3791/55503-v

•

09:32 min
April 13, 2017

•

7 Views
, , , , ,
1German Center for Neurodegenerative Diseases (DZNE), 2Centre for Prions and Protein Folding Diseases & Department of Biochemistry,University of Alberta

概要

Automatically generated

Peripheral injection of alpha-synuclein fibrils into the peritoneum or tongue of Tg(M83+/-:Gfap-luc+/-) mice, which express human alpha-synuclein with the familial A53T mutation and firefly luciferase, can induce neuropathology, including neuroinflammation, in their central nervous system.

Explore More Videos

Bioluminescence ImagingNeuroinflammationTransgenic MiceAlpha-synuclein FibrilsParkinson’s DiseaseNoninvasive MonitoringAnesthesiaIntranasal InoculationIntraperitoneal InjectionNerve InflammationNeurological Disease

Read Article

Cite this Article

Breid, S., Bernis, M. E., Tachu, J. B., Garza, M. C., Wille, H., Tamgüney, G. Bioluminescence Imaging of Neuroinflammation in Transgenic Mice After Peripheral Inoculation of Alpha-Synuclein Fibrils. J. Vis. Exp. (122), e55503, doi:10.3791/55503 (2017).

Download .ris file

Copy

Share Video

.

Copy