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An In Vitro Model for the Study of Cellular Pathophysiology in Globoid Cell Leukodystrophy
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JoVE Journal Nörobilim
An In Vitro Model for the Study of Cellular Pathophysiology in Globoid Cell Leukodystrophy

An In Vitro Model for the Study of Cellular Pathophysiology in Globoid Cell Leukodystrophy

7,806 Views

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07:45 min

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October 21, 2014

DOI:

10.3791/51903-v

DOI:
10.3791/51903-v

•

07:45 min
October 21, 2014

•

1 Views
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1Nörobilim Bölümü,University of Connecticut Health Center, 2Anatomi ve Hücre Biyolojisi Anabilim Dalı,University of Illinois at Chicago

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Globoid cells are a defining pathological feature of Krabbe disease, a leukodystrophy currently lacking an effective long-term therapy. We have developed a cell culture model to study the innate biology and pathogenic potential of activated microglia and their transformation into globoid cells.

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Claycomb, K. I., Johnson, K. M., Bongarzone, E. R., Crocker, S. J. An In Vitro Model for the Study of Cellular Pathophysiology in Globoid Cell Leukodystrophy. J. Vis. Exp. (92), e51903, doi:10.3791/51903 (2014).

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