Waiting
Processando Login

Trial ends in Request Full Access Tell Your Colleague About Jove
Journal / Neuroscience / An In Vitro Model for the Study of Cellular…
JoVE Journal
Neuroscience

É necessário ter uma assinatura JoVE para assistir este Faça login ou comece sua avaliação gratuita.

JoVE Journal Neuroscience
An In Vitro Model for the Study of Cellular Pathophysiology in Globoid Cell Leukodystrophy
 

An In Vitro Model for the Study of Cellular Pathophysiology in Globoid Cell Leukodystrophy

Article DOI: 10.3791/51903-v • 07:45 min • October 21st, 2014
October 21st, 2014 •
1, 1, 2, 1
1Department of Neuroscience, University of Connecticut Health Center, 2Department of Anatomy and Cell Biology, University of Illinois at Chicago

Capítulos

Resumo
Automatic Translation

Globoid cells are a defining pathological feature of Krabbe disease, a leukodystrophy currently lacking an effective long-term therapy. We have developed a cell culture model to study the innate biology and pathogenic potential of activated microglia and their transformation into globoid cells.

Tags

In Vitro Model Cellular Pathophysiology Globoid Cell Leukodystrophy Multi-nucleated Microglia Central Nervous System Primary Murine Glial Culture System Psychosine Treatment Multinucleation Matrix Metalloproteinase (MMP)-3 Therapeutic Manipulation
Read Article

Get cutting-edge science videos from JoVE sent straight to your inbox every month.

Waiting X
Simple Hit Counter