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An In Vitro Model for the Study of Cellular Pathophysiology in Globoid Cell Leukodystrophy
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JoVE Journal 神経科学
An In Vitro Model for the Study of Cellular Pathophysiology in Globoid Cell Leukodystrophy

An In Vitro Model for the Study of Cellular Pathophysiology in Globoid Cell Leukodystrophy

7,806 Views

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07:45 min

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October 21, 2014

DOI:

10.3791/51903-v

DOI:
10.3791/51903-v

•

07:45 min
October 21, 2014

•

1 Views
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1神経科学科,University of Connecticut Health Center, 2解剖・細胞生物学科,University of Illinois at Chicago

概要

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Globoid cells are a defining pathological feature of Krabbe disease, a leukodystrophy currently lacking an effective long-term therapy. We have developed a cell culture model to study the innate biology and pathogenic potential of activated microglia and their transformation into globoid cells.

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Cite this Article

Claycomb, K. I., Johnson, K. M., Bongarzone, E. R., Crocker, S. J. An In Vitro Model for the Study of Cellular Pathophysiology in Globoid Cell Leukodystrophy. J. Vis. Exp. (92), e51903, doi:10.3791/51903 (2014).

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