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焦点放射線阻害と大人の視床下部ニューロン新生の機能的な尋問
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11:45 min
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November 14, 2013
DOI:
1Division of Biology,California Institute of Technology, 2Solomon H. Snyder Department of Neuroscience, Neurology, and Ophthalamology,Johns Hopkins University School of Medicine, 3Department of Radiation Oncology & Molecular Radiation Sciences,Johns Hopkins University School of Medicine, 4Radyasyon Onkoloji Bölümü,University Of Washington Medical Center, 5Institute for Cell Engineering and High-Throughput Biology Center,Johns Hopkins University School of Medicine
Özet
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アダルト生まれの哺乳動物の神経細胞の機能は、調査のアクティブエリアのまま。電離放射線は、新たな神経細胞の誕生を阻害する。コンピュータ断層撮影誘導焦点照射（CFIR）を用いて、特定の神経前駆細胞集団の三次元解剖学的ターゲティングは現在、成体神経新生の機能的役割を評価するために使用することができる。
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Lee, D. A., Salvatierra, J., Velarde, E., Wong, J., Ford, E. C., Blackshaw, S. Functional Interrogation of Adult Hypothalamic Neurogenesis with Focal Radiological Inhibition. J. Vis. Exp. (81), e50716, doi:10.3791/50716 (2013).
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