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In Silico Structural Analysis of Protein Carbonylation by Lipid Derivatives
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Author Spotlight: In Silico Creation and Impact of Carbonylated Amino Acids on Protein Structure and Function
JoVE Journal
Bioquímica
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JoVE Journal Bioquímica
Synthesizing Amino Acids Modified with Reactive Carbonyls in Silico to Assess Structural Effects Using Molecular Dynamics Simulations

Author Spotlight: In Silico Creation and Impact of Carbonylated Amino Acids on Protein Structure and Function

In Silico Structural Analysis of Protein Carbonylation by Lipid Derivatives

DOI:
10.3791/66605-v

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01:55 min

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April 26, 2024

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, , , , ,
1Analytical Chemistry and Biomedicine Group, Exact and Natural Sciences Faculty,University of Cartagena, 2Analytical Chemistry and Biomedicine Group, Pharmaceutical Sciences Faculty,University of Cartagena, 3Pharmacology and Therapeutics Research Group,University of Cartagena

Tags

Protein CarbonylationReactive Carbonyl SpeciesLipid Peroxidation4-hydroxy-2-nonenal (HNE)4-hydroxy-2-hexenal (HHE)4-Oxo-2-nonenal (ONE)Malondialdehyde (MDA)Molecular Dynamics SimulationsStructural ChangesAmino Acid ModificationThioredoxinBovine Serum AlbuminZu-5-ankyrin Domain

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