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使用系绳上的锍中心构建环肽

JoVE Journal
Química

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JoVE Journal Química

Constructing Cyclic Peptides Using an On-Tether Sulfonium Center

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使用系绳上的锍中心构建环肽

2,423 Views

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07:11 min

•

September 28, 2022

DOI:

10.3791/64289-v

DOI:

10.3791/64289-v

•

07:11 min

September 28, 2022

•

6 Views

Chunli Song*¹, Zhanfeng Hou*^1,2, Zijun Jiao*¹, Zhaodi Liu³, Chenshan Lian^1,2, Min Zhang¹, Wei Liang³, Feng Yin^1,2, Zigang Li^1,2

¹Pingshan Translational Medicine Center,Shenzhen Bay Laboratory, ²Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology,Peking University Shenzhen Graduate School, ³Department of Radiation Oncology, the First Affiliated Hospital,Anhui Medical University

Summary

该协议介绍了通过半胱氨酸和蛋氨酸之间的双烷基化以及由炔丙基锍中心触发的简单硫醇 - 炔反应合成环肽。

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