Rivista
/
Chimica
/
Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
JoVE Journal
Chimica
È necessario avere un abbonamento a JoVE per visualizzare questo.  Accedi o inizia la tua prova gratuita.
JoVE Journal Chimica
Constructing Cyclic Peptides Using an On-Tether Sulfonium Center

Constructing Cyclic Peptides Using an On-Tether Sulfonium Center

2,423 Views

•

07:11 min

•

September 28, 2022

DOI:

10.3791/64289-v

DOI:
10.3791/64289-v

•

07:11 min
September 28, 2022

•

6 Views
, , , , , , , ,
1Pingshan Translational Medicine Center,Shenzhen Bay Laboratory, 2Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology,Peking University Shenzhen Graduate School, 3Department of Radiation Oncology, the First Affiliated Hospital,Anhui Medical University

Summary

Automatically generated

This protocol presents the synthesis of cyclic peptides via bisalkylation between cysteine and methionine and the facile thiol-yne reaction triggered by the propargyl sulfonium center.

Explore More Videos

Cyclic PeptideSulfonium CenterCysteineN-terminal DeprotectionPeptide CouplingNinhydrin TestResin WashingTrityl-L-cysteine Deprotection

Read Article

Cite this Article

Song, C., Hou, Z., Jiao, Z., Liu, Z., Lian, C., Zhang, M., Liang, W., Yin, F., Li, Z. Constructing Cyclic Peptides Using an On-Tether Sulfonium Center. J. Vis. Exp. (187), e64289, doi:10.3791/64289 (2022).

Download .ris file

Copy

Share Video

.

Copy