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Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
JoVE Journal
Chemistry
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JoVE Journal Chemistry
Constructing Cyclic Peptides Using an On-Tether Sulfonium Center

Constructing Cyclic Peptides Using an On-Tether Sulfonium Center

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07:11 min

September 28, 2022

DOI:

07:11 min
September 28, 2022

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Summary

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This protocol presents the synthesis of cyclic peptides via bisalkylation between cysteine and methionine and the facile thiol-yne reaction triggered by the propargyl sulfonium center.

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