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使用聚焦扫描超声将抗体输送到大脑中
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Neurociência
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JoVE Journal Neurociência
Delivery of Antibodies into the Brain Using Focused Scanning Ultrasound
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使用聚焦扫描超声将抗体输送到大脑中

2,791 Views

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07:34 min

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July 18, 2020

DOI:

10.3791/61372-v

DOI:
10.3791/61372-v

•

07:34 min
July 18, 2020

•

5 Views
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1Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute,The University of Queensland

Summary

Automatically generated

这里介绍的是一种方案，用于局部或整个小鼠大脑短暂打开血脑屏障（BBB），以传递荧光标记的抗体并激活小胶质细胞。还提出了一种通过组织学检测抗体递送和小胶质细胞活化的方法。

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Cite this Article

Leinenga, G., Bodea, L., Koh, W. K., Nisbet, R. M., Götz, J. Delivery of Antibodies into the Brain Using Focused Scanning Ultrasound. J. Vis. Exp. (161), e61372, doi:10.3791/61372 (2020).

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