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Delivery of Antibodies into the Brain Using Focused Scanning Ultrasound
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July 18, 2020
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Presented here is a protocol to transiently open the blood-brain barrier (BBB) either focally or throughout a mouse brain to deliver fluorescently-labeled antibodies and activate microglia. Also presented is a method to detect the delivery of antibodies and microglia activation by histology.
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Leinenga, G., Bodea, L., Koh, W. K., Nisbet, R. M., Götz, J. Delivery of Antibodies into the Brain Using Focused Scanning Ultrasound. J. Vis. Exp. (161), e61372, doi:10.3791/61372 (2020).
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