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Stereological Estimation of Cholinergic Fiber Length in the Nucleus Basalis of Meynert of the Mouse Brain
 

Stereological Estimation of Cholinergic Fiber Length in the Nucleus Basalis of Meynert of the Mouse Brain

Article DOI: 10.3791/60405-v • 09:15 min • February 5th, 2020
February 5th, 2020 •
1, 1, 1,2,3,4
1Laboratory for Alzheimer's Disease and Aging Research, Kansas City Veterans Affairs Medical Center, 2Department of Neurology, University of Kansas Medical Center, 3Department of Molecular and Integrative Physiology, University of Kansas Medical Center, 4The University of Kansas Alzheimer's Disease Center

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Neuronal fiber length within a three-dimensional structure of a brain region is a reliable parameter to quantify specific neuronal structural integrity or degeneration. This article details a stereological quantification method to measure cholinergic fiber length within the nucleus basalis of Meynert in mice as an example.

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Stereological Estimation Cholinergic Fiber Length Nucleus Basalis Of Meynert Mouse Brain Neurodegeneration Neuronal Fiber Loss Three-dimensional Quantification Computer-based Unbiased Fractionation Space Balls Line-like Structures 3D Measurement Prabhakar Singh David Peng Post-doc Research Assistant Transcardial Perfusion DPBS PFA Post-fixation Brain Washing Sucrose Solution Cryotome Chamber
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