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Intact Histological Characterization of Brain-implanted Microdevices and Surrounding Tissue
JoVE Journal
Neurociência
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JoVE Journal Neurociência
Intact Histological Characterization of Brain-implanted Microdevices and Surrounding Tissue

Intact Histological Characterization of Brain-implanted Microdevices and Surrounding Tissue

16,574 Views

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11:31 min

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February 11, 2013

DOI:

10.3791/50126-v

DOI:
10.3791/50126-v

•

11:31 min
February 11, 2013

•

3 Views
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1Weldon School of Biomedical Engineering,Purdue University, 2Department of Biological Sciences,Purdue University

Summary

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Here we present a histological method for capturing, labeling, optically clearing, and imaging the intact brain tissue interface around chronically implanted microdevices in rodent brain tissue. Results from the techniques comprising this method are useful for understanding the impact of various penetrating brain-implants on their surrounding tissue.

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Cite this Article

Woolley, A. J., Desai, H. A., Gaire, J., Ready, A. L., Otto, K. J. Intact Histological Characterization of Brain-implanted Microdevices and Surrounding Tissue. J. Vis. Exp. (72), e50126, doi:10.3791/50126 (2013).

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