Here we present a histological method for capturing, labeling, optically clearing, and imaging the intact brain tissue interface around chronically implanted microdevices in rodent brain tissue. Results from the techniques comprising this method are useful for understanding the impact of various penetrating brain-implants on their surrounding tissue.
Woolley, A. J., Desai, H. A., Gaire, J., Ready, A. L., Otto, K. J. Intact Histological Characterization of Brain-implanted Microdevices and Surrounding Tissue. J. Vis. Exp. (72), e50126, doi:10.3791/50126 (2013).