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Optimization of the Ugi Reaction Using Parallel Synthesis and Automated Liquid Handling
JoVE 신문
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JoVE 신문 생물학
Optimization of the Ugi Reaction Using Parallel Synthesis and Automated Liquid Handling

Optimization of the Ugi Reaction Using Parallel Synthesis and Automated Liquid Handling

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08:24 min

November 11, 2008

DOI:

08:24 min
November 11, 2008

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Summary

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The Ugi reaction has proved to be a convenient way to quickly create diverse libraries of compounds. It involves the reaction of an amine, an aldehyde, a carboxylic acid and an isonitrile typically in methanol at room temperature. In this video, we utilize a 48-slot Mettler-Toledo MiniBlock equipped with filtration tubes and a Mettler-Toledo MiniMapper automated liquid handler was used to deliver the reagents and solvent. The parameters of interest were the concentration, the solvent composition and the excess of some of the reagents.

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