Waiting
로그인 처리 중...

Trial ends in Request Full Access Tell Your Colleague About Jove
Journal / Biology / Optimization of the Ugi Reaction Using Parallel…
JoVE Journal
Biology

이 콘텐츠은(는) 무료 액세스입니다.

JoVE Journal Biology
Optimization of the Ugi Reaction Using Parallel Synthesis and Automated Liquid Handling
 

Optimization of the Ugi Reaction Using Parallel Synthesis and Automated Liquid Handling

Article DOI: 10.3791/942-v • 08:25 min • November 11th, 2008
November 11th, 2008 •
1, 1, 2, 3, 1
1Department of Chemistry, Drexel University, 2Mettler-Toledo, 3Chemspider

챕터

요약
Automatic Translation

The Ugi reaction has proved to be a convenient way to quickly create diverse libraries of compounds. It involves the reaction of an amine, an aldehyde, a carboxylic acid and an isonitrile typically in methanol at room temperature. In this video, we utilize a 48-slot Mettler-Toledo MiniBlock equipped with filtration tubes and a Mettler-Toledo MiniMapper automated liquid handler was used to deliver the reagents and solvent. The parameters of interest were the concentration, the solvent composition and the excess of some of the reagents.

Tags

Optimization Ugi Reaction Parallel Synthesis Automated Liquid Handling Furfurylamine Benzaldehyde Boc-glycine T-butylisocyanide Concentration Solvent Reagents Product Isolation Filtration Wash Procedure Yield Methanol Imine Equimolar Concentration Superior Yields Solvent Systems Reproducibility Precipitate Yields
Read Article

Get cutting-edge science videos from JoVE sent straight to your inbox every month.

Waiting X
Simple Hit Counter