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Methods for Studying Uterine Contributions to Pregnancy Establishment in an Ovariectomized Mouse Model
1Biomedicine Discovery Institute, Department of Anatomy and Developmental Biology,Monash University, 2Gynaecology Research Centre, Royal Women’s Hospital and Department of Obstetrics and Gynaecology,University of Melbourne, 3The Ritchie Centre, Hudson Institute for Medical Research and Department of Obstetrics and Gynaecology,Monash University
Chapters
- 00:04Introduction
- 00:54Murine Ovariectomy
- 03:09Slow-Release Hormone Pellet Preparation
- 04:35Artificial Decidualization
- 05:51Results: A Well-Characterized Model of Murine Uterine Artificial Decidualization
- 06:05Conclusion
Pregnancy establishment is a dynamic process involving complex embryo and uterine crosstalk. The precise contributions of the maternal uterine environment to these processes remain an active area of investigation. Here, detailed protocols are provided to aid in designing in vivo animal models to address these research questions.
