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高分辨率中子光谱研究蛋白质和水合水的皮秒纳秒动力学
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High-Resolution Neutron Spectroscopy to Study Picosecond-Nanosecond Dynamics of Proteins and Hydration Water
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高分辨率中子光谱研究蛋白质和水合水的皮秒纳秒动力学

1,545 Views

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08:48 min

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April 28, 2022

DOI:

10.3791/63664-v

DOI:
10.3791/63664-v

•

08:48 min
April 28, 2022

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4 Views
, , , , , , ,
1Institut für Angewandte Physik,Universität Tübingen, 2Institut Max von Laue – Paul Langevin (ILL), 3Institut de Biologie Structurale,Université Grenoble Alpes, 4Institut Européen de Chimie et Biologie, Bordeaux INP, Chimie et Biologie des Membranes et des Nanoobjets (CBMN),Université de Bordeaux

Summary

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中子背散射光谱法提供了对蛋白质及其水合水合的ps-ns动力学的无损和无标记访问。该工作流程介绍了两项关于淀粉样蛋白的研究：关于溶菌酶在聚集过程中的时间分辨动力学和纤维形成时tau的水合水动力学。

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Cite this Article

Pounot, K., Appel, M., Beck, C., Weik, M., Schirò, G., Fichou, Y., Seydel, T., Schreiber, F. High-Resolution Neutron Spectroscopy to Study Picosecond-Nanosecond Dynamics of Proteins and Hydration Water. J. Vis. Exp. (182), e63664, doi:10.3791/63664 (2022).

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