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Biochemistry

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JoVE Journal Biochemistry
High-Resolution Neutron Spectroscopy to Study Picosecond-Nanosecond Dynamics of Proteins and Hydration Water
 

High-Resolution Neutron Spectroscopy to Study Picosecond-Nanosecond Dynamics of Proteins and Hydration Water

Article DOI: 10.3791/63664-v • 08:48 min • April 28th, 2022
April 28th, 2022 •
1,2, 2, 1,2, 3, 3, 4, 2, 1
1Institut für Angewandte Physik, Universität Tübingen, 2Institut Max von Laue - Paul Langevin (ILL), 3Institut de Biologie Structurale, Université Grenoble Alpes, 4Institut Européen de Chimie et Biologie, Bordeaux INP, Chimie et Biologie des Membranes et des Nanoobjets (CBMN), Université de Bordeaux

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Neutron backscattering spectroscopy offers a nondestructive and label-free access to the ps-ns dynamics of proteins and their hydration water. The workflow is presented with two studies on amyloid proteins: on the time-resolved dynamics of lysozyme during aggregation and on the hydration water dynamics of tau upon fiber formation.

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Keywords: Neutron Backscattering Neutron Spectroscopy Protein Dynamics Hydration Water Picosecond-nanosecond Timescale Alzheimer's Parkinson's Sample Preparation Hydrogen-deuterium Exchange
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