Journal
/
생화학
/
Synthesis of Masarimycin, a Small Molecule Inhibitor of Gram-Positive Bacterial Growth
JoVE 신문
생화학
JoVE 비디오를 활용하시려면 도서관을 통한 기관 구독이 필요합니다.  전체 비디오를 보시려면 로그인하거나 무료 트라이얼을 시작하세요.
JoVE 신문 생화학
Synthesis of Masarimycin, a Small Molecule Inhibitor of Gram-Positive Bacterial Growth

Synthesis of Masarimycin, a Small Molecule Inhibitor of Gram-Positive Bacterial Growth

2,215 Views

•

09:10 min

•

January 07, 2022

DOI:

10.3791/63191-v

DOI:
10.3791/63191-v

•

09:10 min
January 07, 2022

•

4 Views
, ,
1Department of Science and Technology,Bryant University, 2Center for Health and Behavioral Sciences,Bryant University

Summary

Automatically generated

A detailed protocol is presented for preparing the bacteriostatic diamide masarimycin, a small molecule probe that inhibits the growth of Bacillus subtilis and Streptococcus pneumoniae by targeting cell wall degradation. Its application as a chemical probe is demonstrated in synergy/antagonism assays and morphological studies with B. subtilis and S. pneumoniae.

Explore More Videos

MasarimycinGram-positive BacteriaAutolysin InhibitorBacterial Growth InhibitorOrganic SynthesisCyclohexylamineCyclohexyl CarboxaldehydeOrtho-iodobenzoic AcidCyclohexyl IsocyanideMethanolThin-layer ChromatographyEthyl AcetateHydrochloric AcidSodium BicarbonateSodium ChlorideSodium Sulfate

Read Article

Cite this Article

Gallati, M., Point, B., Reid, C. W. Synthesis of Masarimycin, a Small Molecule Inhibitor of Gram-Positive Bacterial Growth. J. Vis. Exp. (179), e63191, doi:10.3791/63191 (2022).

Download .ris file

Copy

Share Video

.

Copy