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帕金森病的6-羟基多巴胺大鼠模型

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신경과학
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The 6-hydroxydopamine Rat Model of Parkinson’s Disease

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帕金森病的6-羟基多巴胺大鼠模型

8,168 Views

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08:10 min

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October 27, 2021

DOI:

10.3791/62923-v

DOI:

10.3791/62923-v

•

08:10 min

October 27, 2021

•

165 Views

Rayanne Poletti Guimarães¹, Danilo Leandro Ribeiro¹, Keila Bariotto dos Santos¹, Lívea Dornela Godoy¹, Mirella Rosine Corrêa¹, Fernando Eduardo Padovan-Neto¹

¹Department of Psychology, Faculty of Philosophy, Sciences and Letters of Ribeirão Preto,University of São Paulo

Summary

6-羟基多巴胺（6-OHDA）模型已经使用了几十年，以推进对帕金森病的理解。在该协议中，我们展示了如何通过在内侧前脑束中注射6-OHDA来执行大鼠的单侧黑质纹状体病变，评估运动缺陷并使用步进测试预测病变。

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