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The 6-hydroxydopamine Rat Model of Parkinson’s Disease
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JoVE Journal 神経科学
The 6-hydroxydopamine Rat Model of Parkinson’s Disease

The 6-hydroxydopamine Rat Model of Parkinson’s Disease

8,335 Views

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08:10 min

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October 27, 2021

DOI:

10.3791/62923-v

DOI:
10.3791/62923-v

•

08:10 min
October 27, 2021

•

165 Views
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1Department of Psychology, Faculty of Philosophy, Sciences and Letters of Ribeirão Preto,University of São Paulo

概要

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The 6-hydroxydopamine (6-OHDA) model has been used for decades to advance the understanding of Parkinson's Disease. In this protocol, we demonstrate how to perform unilateral nigrostriatal lesions in the rat by injecting 6-OHDA in the medial forebrain bundle, assess motor deficits, and predict lesions using the stepping test.

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6-hydroxydopamineParkinson’s DiseaseRat ModelNigrostriatal LesionsMedial Forebrain BundleStepping TestMotor DeficitsDopaminergic NeuronsSubstantia NigraNeurodegeneration

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Cite this Article

Guimarães, R. P., Ribeiro, D. L., dos Santos, K. B., Godoy, L. D., Corrêa, M. R., Padovan-Neto, F. E. The 6-hydroxydopamine Rat Model of Parkinson's Disease. J. Vis. Exp. (176), e62923, doi:10.3791/62923 (2021).

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