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T 細胞受容体を介してライブラリ化学阻害剤のスクリーニングのメディエーターの同定
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면역학 및 감염병학
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JoVE 신문 면역학 및 감염병학
Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries
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T 細胞受容体を介してライブラリ化学阻害剤のスクリーニングのメディエーターの同定

8,787 Views

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08:49 min

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January 22, 2019

DOI:

10.3791/58946-v

DOI:
10.3791/58946-v

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08:49 min
January 22, 2019

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1Department of Microbiology and Immunology, Yong Loo Lin School of Medicine,National University of Singapore, 2Singapore Immunology Network,A*STAR, 3Curiox Biosystems, 4Department of Immunobiology, Rega Institute for Medical Research,Katholieke Universiteit (KU) Leuven

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T-cell Receptor SignalingChemical Inhibitor LibrariesHigh-throughput AssayTCR Signaling MediatorsImmune DiseasesThymocytesKinase InhibitorsAnti-CD3/CD28 BeadsApoptosis

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Chen, E. W., Ke, C. Y., Brzostek, J., Gascoigne, N. R. J., Rybakin, V. Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries. J. Vis. Exp. (143), e58946, doi:10.3791/58946 (2019).

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